Buy Velpaclear Abbott Medicine uses, Side effects, Price, Cost India.

Drug Prescribing Information of Velpaclear tablets:

velpaclear tablet is used in following conditions like;

Patients suffered from compensated cirrhosis or without cirrhosis.

Patients with decompensated with long-lasting condition used in combination with ribavirin.

velpaclear  are used in the conditions like hepatitis C viral infection in adolescents; HCV infection is caused by various genotypes like I, II, III, IV, V or VI.

Velpaclear

Drug profile:

Trade name: Velpaclear

Composition: Sofosbuvir & Velpatasvir

Strength of the components: 400mg & 100mg respectively

Manufacturer name: Abbott

Package: 28 tablets in a container

Classification: Anti-hepaciviral drug.

Mechanism of Action of Velpaclear:

A velpaclear tablet containing directly acting anti-viral agents such as sofosbuvir & Velpatasvir which expels their actions by undergoing some mechanism includes;

velpaclear  is an inhibitor of HCV NS5B RNA dependent RNA polymerase, an enzyme essential for viral production. Hence this inhibition causes depletion in viral proliferation.

velpaclear  is an inhibitor of HCV NS5A is a pan genotype, NS5A is a protein required for HCV viral replication thus the inhibition leads to reduce the production of HCV virus in the human body.

Absorption:

If gastric pH level increases lead to cause depletes insolubility of velpaclear tablet.

The peak concentration time of both velpaclear  occurs within 0.5 to 1 hour and 3 hours respectively.

The peak plasma concentration of velpaclear tablet exist in 567ng/ml & 259ng/ml respectively.

Distribution:

The human plasma protein bound to sofosbuvir and Velpatasvir with the range of 61 to 65% and >99.5% respectively.

Metabolism:

Sofosbuvir is metabolized hepatically, with the help of cathepsin A, CES1 & HINT1.

velpaclear is a substrate of P-gp transporter and breast cancer resistance protein.

velpaclear tablet is partially metabolized and it is excreted as an unchanged form.

Elimination:

The mean terminal half-life period of both velpaclear tablet and the circulating metabolite called GS-331007 are reaching at 0.5 hours, 15 hours, & 27 hours respectively.

The main routes of excretion of all the components like;

Sofosbuvir by metabolism; velpaclear through bile in unchanged form & GS-331007 through glomerular filtration and active tubular secretion.

Urine:

Sofosbuvir: 80%; Velpatasvir: 14%
Feces:

Sofosbuvir: 0.4%; Velpatasvir: 94%

When to take the Tablet Velpaclear:

velpaclear tablet should be taken with or without food.

To administer the velpaclear frequently at the same time every day, as a single dose.

If concomitant with ribavirin, velpaclear tablet must be taken with food.

Gastric pH increasing drugs causes depletion in effect of serum concentration of Velpatasvir, to avoid these complications consume the antacids, H2 antagonist and proton pump inhibitors before the dose of velpaclear .

Dosage Regimens of Velpaclear tablets:

Before initiating the therapy, patients should be examined by counting the hepatitis B surface antigen and hepatitis B core antibody (HBsAg & Anti-HBc) to prevent the problem like reactivation of HBV infection.

The prescribed dosage of velpaclear tablet includes as;

velpaclear  containing fixed-dose combination drugs like 400mg of sofosbuvir and 100mg of Velpatasvir.

Recommended velpaclear tablet in patients with chronic HCV infection related to genotypes like I, II, III, IV, V or VI.

Patients with child Pugh A: one tablet of velpaclear  should be administered as a single dose.

Patients with chronic cirrhosis or decompensated (child B or C): velpaclear tablet should be combined with ribavirin.

The ribavirin dosage should be administered on the basis of the weight of the patients.

Less than 75kg: 1000mg per day; at least75kg: 1200mg per day.

No dosage adjustment is required for renal impaired patients.

Drug Called side effects:

Some effects may occur during the therapy of velpaclear tablet;

Nausea

Insomnia

Asthenia

Elevate lipase level

Depression

Headache

Fatigue

Anemia

Rash

Elevation of creatinine kinase

Life-threatening condition like severe symptomatic bradycardia occurs while co-administration with amiodarone.

Drug Interaction of Velpaclear:

velpaclear combining with HMG CoA reductase agents leads to increase the concentration of these agents.

velpaclear tablet concomitant with acid-reducing agents causes the decrease in the effect of concentration of Velpatasvir.

velpaclear  are P-gp & BCRP drug transporters substrate while combining Velpaclear with P-gp inducers causes depletion in plasma concentration of Velpaclear tablet leads to reduce the curative effect.

velpaclear tablet concurrently used with anti-mycobacterial causes depletion of Velpaclear tablet.

velpaclear with amiodarone causes serious bradycardia.

velpaclear tablet combined with digoxin causes increasing the serum concentration of digoxin.

velpaclear  with anticonvulsants causes depletion of the effect of concentration of Velpaclear tablet.

velpaclear  combined with HIV anti-retroviral agents leads to cause decrease the serum concentration of Velpatasvir.

Food -Drug Interactions:

No food-drug interaction occurs, an herbal product like st. Johns wort combining with velpaclear tablet causes decreasing the therapeutic effect of velpaclear 

Possible Contraindications:

The anaphylactic reaction occurs while patients are contraindicated to the components present in a velpaclear tablet.

velpaclear  while using alone it is safe if it is combined with ribavirin which is contraindicated in pregnant women.

Safety Measures:

Ribavirin with Velpaclear tablets in chronic condition causes ill to pregnant women cause fetal harm.

Serious bradycardia occurs while combining with amiodarone.

While taking velpaclear tablet some adverse effects occur, to avoid these conditions some precautions should be taken.

Care should be taken in renal and hepatic impaired patients.

After completion of therapy, reactivation of HBV infection occurs in the patients who are co-infected with HCV/HBV infections, to avoid these conditions investigate the patient by measuring HBsAg and anti-HBc.

Reduction in the therapeutic effect of velpaclear , while the concomitant use of Velpaclear with P-gp inducers.

Pregnancy and Lactation:

velpaclear tablet used alone then its pregnancy category comes under B1; safe to use.

If velpaclear combined with ribavirin, pregnancy category is X; causes fetal death.

Breastfeeding should not be recommended during therapy.

Storage and Handling:

velpaclear tablet container should be stored at room temperature below 30oC.

Keep the container away from moisture, heat, and light.

Missed dose:

velpaclear tablet is not a normal drug, it is prescription medicine used only by the patients who are all having a valid prescription.

If the patient fails to take the dose of the velpaclear , must get advice from a physician and take the medicine within the time because it is single dose therapy.

Otherwise, the missed dose should be skipped and follow the regular dosing schedule

Overdosage:

No distinct antidote is applicable for overdosing of velpaclear tablet; once the overdose occurs to confirm the presence of toxicity.

Treatment:

Check the crucial manifestations and give adjuvant measures.

The Hemodialysis is another method used in an overdose of velpaclear tablet, can efficiently dispose of the dominant circulating metabolite of sofosbuvir, GS-331007 with eradicating ration of 53%.

Hence velpaclear  is highly bound to the human plasma protein; it is not cleared by hemodialysis and gives incredible results.

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