HEPBEST (TENOFOVIR ALAFENAMIDE)
Hepbest 25mg
Drug Profile
Hepbest tablet is an anti-viral agent which is active against HIV infections and HBV infection
Hepbest containing tenofovir Alafenamide has potent anti-retroviral activity, it is prescription medicine used by patients after getting advice from the physician who are well trained
Hepbest is an oral tablet, containing 25 mg of tenofovir Alafenamide as a drug
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| Hepbest |
PRODUCT DETAILS:
Trade name: HepbestActive component: Tenofovir Alafenamide
Strength: 25mg
Mfg: Mylan pharmaceuticals
Pack: 30 tablets in a container
Category: Anti-retro viral activity & Anti-hepaciviral activity
Price :Hepbest tablet price in india
Before starting the treatment, patient must get advice from physician about demerits of the
Hepbest tablet which may occur during or after the therapy
One of the major adverse that occurred after discontinuation of Hepbest tablet, severe acute aggravation of HBV infection, this may happens due to stoppage of tenofovir Alafenamide which is involved in the treatment of hepatitis B infection
HepBest indication
Hepbest tablet contains anti-hepaciviral & anti-retroviral activity
Hepbest are involved in the therapy of
HIV infection
HBV infection in chronic condition
HepBest is a prodrug; TAF is a phosphonoamidate of tenofovir.
TAF has lipophilic cell impermeability effect, which percolates into primary hepatocytes by undergoing passive diffusion and also by hepatic intake Hepbest tablet transporters like OATP1B1 & OATP1B3
Inside the cells, TAF is changed into tenofovir Hepbest by hydrolysis with the help of carboxylesterase present in hepatocytes cells
Again tenofovir Hepbest tablet is phosphorylated into pharmacologically active metabolite tenofovir diphosphate by cellular kinase
This metabolite involved in the inhibition of viral replication Hepbest by insertion into viral DNA by reverse transcriptase, concluded in termination of viral DNA chain
The maximum peak concentration level occurs within 0.48hours after an oral administration
The effect of high fat meal corresponding to fasted state occurs in the range of 1.51 hours & 1.81 hours
HepBest tablet is highly bound to human plasma protein within the range of 80%
The blood to plasma ratio is 1.0%
The metabolism of tenofovir Alafenamide is occurred Hepbest tablet through hepatically with the help of carboxylesterase, cathepsin A & CYP3A
<1% of metabolite through urine
31.7% of metabolites through feces
Nearly 80% of drug gets metabolized in liver
The terminal half life period of Hepbest tablet is 0.51 hours
Lactic acidosis or severe hepatomegaly with steatosis Severe intensive worsening of hepatitis B viral infection
New outset or exacerbation of renal impairment
The main common side effects are
Head ache
Abdominal pain
Fatigue
Cough
Nausea
Back pain
Decreased in serum phosphates level
Depletion in bone mineral density
Glycosuria
Amylase and lipase level increased
Pancreatitis
Hepbest is a substrate of P-gp & breast cancer resistance protein; P-gp & BCRP strong inhibitors are concomitant withHepBest tablets which may Hepbest tabletcause altering the TAF absorption
Hepbest tablett concurrently used with P-gp inducers leads to decrease the TAF absorption, which concluded in depletion of plasma concentration and causes low therapeutic effect
Hepbest co administered with moderate P-gp & BCRP inhibitors causes elevation of absorption and plasma concentration of tenofovir Alafenamide
Mostly tenofovir is excreted via urine, through kidney; combination of Hepbest tablet with the drugs which is reducing the renal function which may causes elevation of tenofovir concentration & renally excreted drugs causes some adverse effects
Examples: Acyclovir, valaciclovir, amino glycosides, Ganciclovir, cidofovir, NSAIDS
HepBest tablet concomitant with anti-convulsants drugs like phenytoin, Phenobarbital, carbamazepine causes decreasing the concentration of TAF
HepBest with anti-mycobacterials like rifabutin, rifampin or rifapentine may leads to decrease the TAF
Tenofovir Alafenamide combined with herbal product like st. Johns wort causes decreasing in serum concentration of tenofovir Alafenamide
Some anaphylactic reactions may occurs if patient are contraindicated to the component present in HepBest tablet
Before initiating the treatment patients must be examine the values of
Serum creatinine
Serum phosphorus
Creatinine clearance
Urine glucose
Urine protein
During the therapy, patients are clinically observed and maintain the values of these levels
No dosage adjustment should be done in both Hepbest renal & hepatic impaired patients
Pediatric:
HepBest tablets, the safety and effectiveness of Hepbest tablet in pediatric patients less than 18 years of age
Hepbest tablet is a single dose regimen; it must be taken as once a day
Hepbest are administered orally with whole some water, it should not be crushed, chew, do not break the tablet
Hepbest tablet should be taken with food
It is a prescription medicine, used only under the guidance of medical practitioner
Conditions like;
Lactic acidosis or serious hepatomegaly with steatosis:
Obesity and extended nucleoside exposure are the risk factors of this condition; if this adverse effect occurs then the therapy with Hepbest tablet should be postponed
After cessation of anti-hepatitis B therapy, severe worsening of hepatitis B viral infection occurs, to prevent this effect patient who are discontinue Hepbest the therapy should be examine frequently to overcome these problem and continue the treatment
Serious risk of advancement of HIV-1 resistance in patients who are co infected with HBV & HIV-1: To control this Hepbest tablet effect, patients who are infected with hepatitis B infection should be monitored with HIV antibody testing before starting the treatment. Anti-retroviral drugs combination also suggested for co infected patients
Aggravation of renal impairment occurs; check Serum creatinine, Serum phosphorus, Creatinine clearance, Urine glucose, Urine protein frequently Hepbest to avoid these problems, otherwise stop the treatment using with Hepbest to escape from renal related adverse effects
Hepbest tablet container should be keep away from moisture, light & heat
Hepbest used in pregnancy condition only after getting advice from medical practitioner
In some group of patients, placental transformation occurs, in such condition HepBest not recommended
Used only under the supervision of medical practitioner
In some patients, breast feeding is Hepbest tablet not recommended for some reasons
Hemodialysis is involved in removing tenofovir (unchanged form) from the blood with the eradicating range of 54%
E-MAIL: millionhealthpharmaceuticals@gmail.com
WEBSITE URL: https://pillsbag.com/products/hepbest-25mg
HepBest warning
Some of the adverse effects Hepbest occurs which may cause life threatening conditionsBefore starting the treatment, patient must get advice from physician about demerits of the
Hepbest tablet which may occur during or after the therapy
One of the major adverse that occurred after discontinuation of Hepbest tablet, severe acute aggravation of HBV infection, this may happens due to stoppage of tenofovir Alafenamide which is involved in the treatment of hepatitis B infection
HepBest indication
Hepbest tablet contains anti-hepaciviral & anti-retroviral activity
Hepbest are involved in the therapy of
HIV infection
HBV infection in chronic condition
HepBest performed its action by
HepBest is a prodrug; TAF is a phosphonoamidate of tenofovir.
TAF has lipophilic cell impermeability effect, which percolates into primary hepatocytes by undergoing passive diffusion and also by hepatic intake Hepbest tablet transporters like OATP1B1 & OATP1B3
Inside the cells, TAF is changed into tenofovir Hepbest by hydrolysis with the help of carboxylesterase present in hepatocytes cells
Again tenofovir Hepbest tablet is phosphorylated into pharmacologically active metabolite tenofovir diphosphate by cellular kinase
This metabolite involved in the inhibition of viral replication Hepbest by insertion into viral DNA by reverse transcriptase, concluded in termination of viral DNA chain
Body works for HepBest after administration
The maximum peak concentration level occurs within 0.48hours after an oral administration
The effect of high fat meal corresponding to fasted state occurs in the range of 1.51 hours & 1.81 hours
HepBest tablet is highly bound to human plasma protein within the range of 80%
The blood to plasma ratio is 1.0%
The metabolism of tenofovir Alafenamide is occurred Hepbest tablet through hepatically with the help of carboxylesterase, cathepsin A & CYP3A
The elimination of HepBest ;
<1% of metabolite through urine
31.7% of metabolites through feces
Nearly 80% of drug gets metabolized in liver
The terminal half life period of Hepbest tablet is 0.51 hours
Side effects caused during therapy
Lactic acidosis or severe hepatomegaly with steatosis Severe intensive worsening of hepatitis B viral infection
New outset or exacerbation of renal impairment
The main common side effects are
Head ache
Abdominal pain
Fatigue
Cough
Nausea
Back pain
Decreased in serum phosphates level
Depletion in bone mineral density
Glycosuria
Amylase and lipase level increased
Pancreatitis
Drug interaction occurred while receiving HepBest
Hepbest is a substrate of P-gp & breast cancer resistance protein; P-gp & BCRP strong inhibitors are concomitant withHepBest tablets which may Hepbest tabletcause altering the TAF absorption
Hepbest tablett concurrently used with P-gp inducers leads to decrease the TAF absorption, which concluded in depletion of plasma concentration and causes low therapeutic effect
Hepbest co administered with moderate P-gp & BCRP inhibitors causes elevation of absorption and plasma concentration of tenofovir Alafenamide
Mostly tenofovir is excreted via urine, through kidney; combination of Hepbest tablet with the drugs which is reducing the renal function which may causes elevation of tenofovir concentration & renally excreted drugs causes some adverse effects
Examples: Acyclovir, valaciclovir, amino glycosides, Ganciclovir, cidofovir, NSAIDS
HepBest tablet concomitant with anti-convulsants drugs like phenytoin, Phenobarbital, carbamazepine causes decreasing the concentration of TAF
HepBest with anti-mycobacterials like rifabutin, rifampin or rifapentine may leads to decrease the TAF
Tenofovir Alafenamide combined with herbal product like st. Johns wort causes decreasing in serum concentration of tenofovir Alafenamide
Reason for withhold the therapy
No contraindication occurred during therapySome anaphylactic reactions may occurs if patient are contraindicated to the component present in HepBest tablet
HepBest dosage
Before starting the therapy, patients should be investigate for HIV-1 infection, in case of HIV-1 infection present, tenofovir Alafenamide should not be used aloneBefore initiating the treatment patients must be examine the values of
Serum creatinine
Serum phosphorus
Creatinine clearance
Urine glucose
Urine protein
During the therapy, patients are clinically observed and maintain the values of these levels
Recommended dosage:
The prescribed dosage of Hepbest tablet is 25mg should be taken as a single dose by administering with foodNo dosage adjustment should be done in both Hepbest renal & hepatic impaired patients
Pediatric:
HepBest tablets, the safety and effectiveness of Hepbest tablet in pediatric patients less than 18 years of age
How to take HepBest tablets
Hepbest tablet is a single dose regimen; it must be taken as once a day
Hepbest are administered orally with whole some water, it should not be crushed, chew, do not break the tablet
Hepbest tablet should be taken with food
It is a prescription medicine, used only under the guidance of medical practitioner
Precaution takes place during the therapy
After completion of therapy, some adverse effects may occur to overcome the problems some precaution may take place;Conditions like;
Lactic acidosis or serious hepatomegaly with steatosis:
Obesity and extended nucleoside exposure are the risk factors of this condition; if this adverse effect occurs then the therapy with Hepbest tablet should be postponed
After cessation of anti-hepatitis B therapy, severe worsening of hepatitis B viral infection occurs, to prevent this effect patient who are discontinue Hepbest the therapy should be examine frequently to overcome these problem and continue the treatment
Serious risk of advancement of HIV-1 resistance in patients who are co infected with HBV & HIV-1: To control this Hepbest tablet effect, patients who are infected with hepatitis B infection should be monitored with HIV antibody testing before starting the treatment. Anti-retroviral drugs combination also suggested for co infected patients
Aggravation of renal impairment occurs; check Serum creatinine, Serum phosphorus, Creatinine clearance, Urine glucose, Urine protein frequently Hepbest to avoid these problems, otherwise stop the treatment using with Hepbest to escape from renal related adverse effects
Storage
Hepbest container should be stored at room temperature at below 30oC (86oF)Hepbest tablet container should be keep away from moisture, light & heat
1.Pregnancy
Hepbest tablet is safe in useHepbest used in pregnancy condition only after getting advice from medical practitioner
In some group of patients, placental transformation occurs, in such condition HepBest not recommended
2. Lactation
No clinical human data is applicableUse with caution
Used only under the supervision of medical practitioner
In some patients, breast feeding is Hepbest tablet not recommended for some reasons
Missed dosage
Hepbest is a prescription medicine, if patients fail to take the dose must be consult with trained physician and take the dose within the time; otherwise the missed dose should be skipped and follow the regular dosing scheduleOver dosage
Generally, Hepbest tablet is a single tablet dose. If over dosage is occur, first patients must examine with toxicity level and secondly hemodialysis takes placeHemodialysis is involved in removing tenofovir (unchanged form) from the blood with the eradicating range of 54%
CONTACT DETAILS:
Phone no: +919940472902E-MAIL: millionhealthpharmaceuticals@gmail.com
WEBSITE URL: https://pillsbag.com/products/hepbest-25mg
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